Research also indicates that pasteurised Akkermansia is even more efficient than its live state because it is able to act all along the gastrointestinal tract instead of solely in the colon.
The beneficial effects include:
DECREASE IN BODY WEIGHT AND FAT MASS GAIN
REDUCTION IN LOW-GRADE INFLAMMATION
A DECREASE IN PLASMA CHOLESTEROL
AN IMPROVEMENT OF INTESTINAL BARRIER FUNCTION*
Helping to prevent metabolic disorders - and more
Restoring the mucus layer to a normal layer of thickness helps it to function better as a barrier, thereby preventing the development of metabolic endotoxemia and reducing the presence of undesirable lipopolysaccharides in the bloodstream. So, simply put, Akkermansia muciniphila helps prevent the metabolic disorders that can be triggered by metabolic endotoxemia and low-grade inflammation – which can include insulin resistance, hepatic inflammation and diabetes.
So, taken together, the preclinical data shows that taking Akkermansia muciniphila as a supplement has several important health benefits:
HELPS WITH YOUR WEIGHT CONTROL
CONTRIBUTES TO THE MAINTENANCE OF YOUR NORMAL BLOOD GLUCOSE LEVELS
RESTORING GUT BARRIER INTEGRITY/PERMEABILITY
A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice, Plovier H. et al. , Nature Medicine, 2016
1 Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, Chilloux J, Ottman N, Duparc T, Lichtenstein L, Myridakis A, Delzenne NM, Klievink J, Bhattacharjee A, van der Ark KC, Aalvink S, Martinez LO, Dumas ME, Maiter D, Loumaye A, Hermans MP, Thissen JP, Belzer C, de Vos WM, Cani PD (2017) A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice. Nat Med 23 (1):107-113. doi:10.1038/nm.4236.
2 Everard, A., et al. (2013). “Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity.” Proc Natl Acad Sci U S A 110(22): 9066-9071.
3 Hasani, A., et al. (2021). “The role of Akkermansia muciniphila in obesity, diabetes and atherosclerosis.” J Med Microbiol 70(10).
4 Jia, B., et al. (2023). “Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease.” Trends Microbiol 31(1): 76-91