Health care professionals

Introduce your patients to the only pasteurised Akkermansia product.

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Akkermansia

With low levels of Akkermansia, toxins and
fat enter the body, leading to excessive weight gain and related diseases such as insulin intolerance, cardiovascular disorders and fatty liver.

Restoring the natural level of Akkermansia is key to overcoming lifestyle diseases and getting back to living a healthier life.

Our unique, natural and innovative food supplement with pasteurised Akkermansia contains natural ingredients that help promote
weight management and control blood sugar.

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Our clinical trial

First placebo controlled human trial published in Nature Medicine in 2019

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Produce a range of pioneering solutions that help people live healthier, happier lives

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Accelerate scientific research and understanding of the medical application of Akkermansia

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Start a global movement that helps liberate people from discomforting thoughts and help them to improve their health

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Reduction of liver inflammatory markers

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Excellent compliance and no side effects

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Mechanism of Action

Akkermansia muciniphila acts as a guardian of the intestinal barrier function through its unique mucus-degrading abilities and its location within the mucus layer.

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Because it uses mucin as the sole source of nutrients, Akkermansia muciniphila is sometimes considered as a “mucin-degrading” bacterium. However, it can be involved in a positive feedback loop.

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Akkermansia

In this loop, it stimulates mucin production through mucin degradation, renewing the mucus layer.

In a healthy human gut, these bacteria maintain mucus production and thickness, thus preventing the invasion of pathogenic bacteria.

Scientific Study

53%

of Europeans over 18 are overweight1

Manage your weight2 and control your glucose level3

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2 EGCG Green Tea: helps with your weight control
3 Chromium: contributes to the maintenance of your normal blood glucose levels

When Akkermansia muciniphila processes mucin, it releases the following components as by-products of this fermentation

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Short-chain fatty acids (SCFA) such as propionate and acetate

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Important factors

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Start a global movement that helps liberate people from discomforting thoughts and help them to improve their health

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Vitamins as by-products of this fermentation

Moreover, supplementation with Akkermansia muciniphila has been associated with a restoration of the gut barrier function in mouse models of obesity. Indeed, optimal Akkermansia muciniphila levels:¹²³
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Maintain the normal permeability of the gut

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Prevent chronic tissue inflammation (e.g. in liver and fat tissues) involved in metabolic disorders

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Prevent pro-inflammatory toxins from entering the bloodstream

Gut barrier immunity
cholesterol
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Pasteurised
Akkermansia

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insulin glucose diabetes liver
Fat mass inflammation

Want to dig a little deeper?

Here’s some further reading that we’ve collated for you

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

Clinical study

We conducted the first randomised double-blind placebo-controlled pilot study to evaluate the effects of pasteurised Akkermansia muciniphila administered in humans.

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The main objectives were to determine the safety, tolerance and metabolic parameters (i.e., insulin resistance, circulating lipids, visceral adiposity, body mass) after 3 months of daily administration in overweight or obese subjects suffering from metabolic syndrome and insulin resistance.

Moreover, the study also looked at the gut barrier function (i.e., plasma lipopolysaccharides) and gut microbiota composition.

HCP-study-diagram

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