We’re here to help. Get to know more about Akkermansia products from formulation to when and how to take them
There are several clinical studies taking place where Akkermansia efficacy data is available highlighting results in those taking the product for between 3 to 6 months. The proof of concept study, where participants took the product for 3 months, indicates an effect on metabolic syndrome with prediabetes and/or lipid disorders in the blood and obesity. 1
In some cases, individuals will feel the benefits of Akkermansia after a few weeks, while others will require more time.
The proof of concept study in humans indicates that taking it daily for three months had a positive effect on the gut barrier, sugar and fat metabolism and liver function in people who have a metabolic syndrome including overweight or obesity and prediabetes. 1
Our preclinical studies and proof of concept trial* found that the pasteurised form of Akkermansia was even more beneficial than the live strain with regards to its effect on gut barrier function, insulin sensitivity, fat mass composition, dyslipidemia and immune homeostasis. What’s more, while pasteurisation, which involves heating at 70 degrees Celsius for 30 minutes, kills other bacterium it leaves Akkermansia’s functionality intact. 1, 2
Chromium is added to Akkermansia to improve insulin sensitivity. It is used in accordance with the EU Health Claims Register claim that Chromium contributes to the maintenance of normal blood glucose concentrations. No, this product is not available without chromium.
Yes, Akkermansia can be taken alongside other products. Akkermansia in its pasteurised form is active in the gut without any known enzymatic drug-microbiome interactions and is subsequently excreted in the stool. As a result, it doesn’t interfere with the metabolism of any drug that is absorbed into the body. It is worth noting, however, that EGCG, a green tea component, can hamper iron absorption.
An Akkermansia booster increases the proportion of living Akkermansia bacteria in the gut. By taking pasteurised Akkermansia, you’re taking the most effective form of the strain with increased benefits for the gut barrier, as well as metabolic and immune parameters. 1, 3
Akkermansia is formulated with a specific amount of EGCG green tea extract to support weight management, as per on hold health claims. It is not actually available without green tea.
*for more information visit our clinical studies page.
1 Depommier, C., et al. (2019). “Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study.” Nat Med 25(7): 1096-1103.
2 Plovier, H., et al. (2017). “A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice.” Nat Med 23(1): 107-113.
3 Wen, J. J., et al. (2023). “Tea polyphenol and epigallocatechin gallate ameliorate hyperlipidemia via regulating liver metabolism and remodeling gut microbiota.” Food Chem 404(Pt A): 134591.