HCP Science

Science

Scientific understanding of the gut microbiome has grown exponentially in recent years and the research world is booming with studies showing that modifications in the intestinal bacteria and inflammation may play a role in the development of many common chronic diseases. 

The Akkermansia Company™ is dedicated to sharing useful articles based on the latest scientific research covering areas relating to the Akkermansia muciniphila strain, gut health and the microbiome.

About Akkermansia muciniphila

First isolated in 2004, Akkermansia muciniphila is a ‘commensal’ bacterium that is found naturally in the gastrointestinal tract of humans and animals. A large body of scientific research indicates its presence in humans is associated with better health. 1
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The Gut Microbiome

The human microbiome consists of the genes that make up the 10-100 trillion microbial cells that make up each person’s microbiota. This collection of microbes is as unique as our fingerprints, and they not only influence how our body responds to certain foods, but also our overall health and well-being. 2
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Safeguarding Gut Barrier Health

The gut barrier manages what comes in and goes out in the gut, and when the function of the gut barrier is disturbed, the gut becomes more permeable leading to dysbiosis, better known as ‘leaky gut’. 3
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The Prevalence of Obesity & Diabetes

For many people, modern life is characterised by a poor-quality diet and sedentary habits that can lead to an imbalance in gut microbiota, known as ‘dysbiosis’. This dysbiosis can, in turn, promote diet-induced obesity and metabolic complications through a variety of mechanisms. 4
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Understanding Irritable Bowel Syndrome

Irritable bowel syndrome, known as IBS for short, is a chronic gastrointestinal disorder affecting the large intestine. It is believed around 1 in 10 people worldwide live with the condition. 5

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Digest

Check out the latest articles from our Digest created by world-leading experts across a variety of fields.

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REFERENCES

1 Derrien M, Belzer C, de Vos WM (2017) Akkermansia muciniphila and its role in regulating host functions. Microb Pathog 106:171-181. doi:10.1016/j.micpath.2016.02.005.

2 Tierney, B. T., et al. (2019). “The Landscape of Genetic Content in the Gut and Oral Human Microbiome.” Cell Host & Microbe 26(2): 283-295.e288

3 Martel, J., et al. (2022). “Gut barrier disruption and chronic disease.” Trends in Endocrinology & Metabolism 33(4): 247-265

4 de Vos, W. M., et al. (2022). “Gut microbiome and health: mechanistic insights.” Gut 71(5): 1020-1032

5 IBS Facts and Statistics, https://aboutibs.org/what-is-ibs/facts-about-ibs/